Hormone Therapy for Breast Cancer


Understanding Hormone Therapy
Many people who have had breast cancer take medications, like tamoxifen and aromatase inhibitors, that help prevent the cancer from coming back. Most people do well on these drugs, with no major issues that interfere with daily life. But there can be side effects like hot flashes, night sweats, mood swings, and joint pain.

Hot Flashes and Night Sweats
Hot flashes and night sweats are common side effects of hormone therapy. To manage these, keep your bedroom cool at night and use breathable, moisture-wicking sleepwear. During the day, dress in layers so you can easily adjust your clothing. Stay hydrated and avoid triggers like caffeine, alcohol, and spicy foods. Some women find relief through relaxation techniques like deep breathing or meditation.

Mood Swings and Emotional Changes
Hormone therapy can affect your mood. You might feel irritable, anxious, or depressed. Consider joining a support group or talking to a therapist who specializes in cancer patients. Regular exercise, including gentle activities such as walking and yoga, can help boost your mood. If your mood changes persist or get worse, discuss them with your health care provider.

Joint Pain and Stiffness
Joint symptoms related to hormone therapy for breast cancer don't usually improve by taking over-the-counter pain relievers such as acetaminophen or ibuprofen. What does work? Some patients find relief with acupuncture. Regular exercise also seems to help.

Vaginal Dryness and Discomfort
Hormone therapy can lead to vaginal dryness and discomfort. This happens because hormone therapy lowers your levels of estrogen. Over-the-counter vaginal lubricants and moisturizers can provide relief during sex. Some women benefit from low-dose topical vaginal estrogen, but the doctor treating you for breast cancer needs to approve this.

Bone Loss and Osteoporosis
Some hormone therapies can increase the risk of osteoporosis. Protect your bone health through weight-bearing exercises like walking, dancing, or light weightlifting. Vitamin D is important for bone health, so consider a supplement if your levels are low. Your doctor may recommend regular bone density scans to monitor your bone health and may prescribe medication if needed.

Severe Side Effects
If the side effects from your hormone therapy are very severe, tell your doctor what you're going through. Whatever you do, don't stop taking your medication without talking to your doctor first. They may be able to offer coping strategies you haven't thought of. Alternatively, they may switch you to another drug.
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SOURCES:
Erica Mayer, MD, MPH, director, Breast Cancer Clinical Research and Institute Physician, the Dana-Farber Cancer Institute, Boston.
Patricia Ganz, MD, director, cancer prevention and control research, Jonsson Comprehensive Cancer Center, University of California-Los Angeles.
Jessica Jones, MD, assistant professor, oncology, the University of Texas Health Science Center McGovern Medical School, Houston.
National Cancer Institute: “Hormone Therapy for Breast Cancer.”
American Society for Clinical Oncology: “Oxybutynin: A Novel Option for Managing Hot Flashes?"
Breastcancer.org: “Using Hormone Replacement Therapy.”
American College of Obstetricians and Gynecologists: “Treatment of Urogenital Symptoms in Individuals With a History of Estrogen-dependent Breast Cancer.”
MGH Center for Women’s Mental Health: “Combining Tamoxifen with Antidepressants: What You Need to Know.”
Current Psychiatry: “Tailoring depression treatment for women with breast cancer.”
Frontiers in Psychology: “Cognitive Behavioral Therapy for Insomnia in Breast Cancer Survivors: A Review of the Literature.”
Cancer: “Electroacupuncture for fatigue, sleep, and psychological distress in breast cancer patients with aromatase inhibitor-related arthralgia: A randomized trial.”
American Cancer Society: “Hormone Therapy for Breast Cancer.”
InformedHealth.org: "Using medication: Topical medications."